The first luminal loop confers insulin responsiveness to glucose transporter 4
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چکیده
منابع مشابه
The first luminal loop confers insulin responsiveness to glucose transporter 4
Glucose transporter isoform 4 (GLUT4), is the sole glucose transporter responsible for the effect of insulin on postprandial blood glucose clearance. However, the nature of the insulin sensitivity of GLUT4 remains unknown. In this study, we replaced the first luminal loop of cellugyrin, a 4-transmembrane protein that does not respond to insulin, with that of GLUT4. The chimera protein is target...
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Insulin-dependent translocation of glucose transporter 4 (Glut4) to the plasma membrane of fat and skeletal muscle cells plays the key role in postprandial clearance of blood glucose. Glut4 represents the major cell-specific component of the insulin-responsive vesicles (IRVs). It is not clear, however, whether the presence of Glut4 in the IRVs is essential for their ability to respond to insuli...
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متن کاملTargeting of the insulin-regulatable glucose transporter (GLUT-4).
668 A family of facilitative glucose transporters (GLUTS 1-7) has recently been identified in mammals [ 11. It is of key interest to determine the unique function of each GLUT isoform in an effort to broaden our understanding of whole body glucose homeostasis. An isoform of relevance to the regulation of glucose metabolism by insulin is GLUT-4. The expression of this isoform is confined to tiss...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2012
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e11-10-0839